What is arthritis

There is an important balance between the level of maintenance and repair equaling the level of wear and tear, in order for joints to stay strong and flexible for the long-term.

Joints begin to degenerate when the level of maintenance and repair DOES NOT meet the level of wear and tear that the joint requires. The end result is osteoarthritis (OA) also known as degenerative joint disease (DJD). Joint stress, performance, aging, repetitive concussion and trauma all contribute to an increased requirement for maintenance and repair, and the key issue is to ensure the correct building blocks are available at all times to meet these increased requirements adequately.

Osteoarthritis is the chronic progressive degeneration of the joint cartilage, narrowing of the joint space, boney changes such as bones spurs, and changes in the synovial membranes.

The process of deterioration is complex but essentially the deteriorating cartilage releases molecules into the synovial fluid that cause inflammation of the synovial membrane.  As a result, this triggers the membrane to release substances that further contribute to the deterioration of the cartilage, including that of enzyme degradation of cartilage.

The joint requires particular substrates to meet normal daily repair and maintenance requirements.  The key building block is Glucosamine Sulphate which is a GAG (glucosaminoglycan) precursor and a substrate for the biochemical pathway responsible for the production of macromolecules involved in joint articulation including chondroitin sulfate (CS) and hyaluronic acid (HA).  The rate-limiting step in the synthesis of these macromolecules is the level of glucosamine sulphate substrate available for incorporation into this biochemical pathway. By providing glucosamine sulphate we can push the biochemical pathway forward and in effect increases the synthesis of GAG’s and thereby provide a means for repair of articular cartilage.